Apomorphine rotation test

Description

The apomorphine test using an rotameter has proved to be a popular test for screening the behavioral effects of a wide variety of lesions, drugs, and other experimental manipulations on the brain of rodents.

This test is widely carried out in experiments using animal models of Parkinson disease with unilateral lesions in the dopaminergic nigrostriatal system in which the number and direction of animal rotations in quantified after apormorphine treatment.

ROTAMETER - SEDACOM (Panlab)

Rotameter
SEDACOM software

Reasons for choosing this test

Rapid and easy-to-do test
Can be entirely automated

Related human disease/applications

Drug screening
Parkinson disease

Research areas

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More information

Panlab | Harvard Apparatus