HOT COLD PLATE

For testing animal sensitivity to pain resulting from exposure to heat or cold

Description
Key features
Specs
How to order
Publications

Description

Panlab Hot/Cold Plate Analgesia Meter is based on a metal plate which can be heated to 65°C and cooled to -3°C (with an ambient temperature between 20°C and 25°C). An electronic thermostat maintains the plate's temperature and a front panel digital thermometer displays the current plate temperature. 

The animal pain sensitivity resulting from exposure to heat or cold is tested by placing the animal on the surface of the plate and starting a built-in timer. The operator stops the timer at the instant the animal lifts its paw from the plate, reacting to the discomfort. The front panel timer then displays the number of seconds the animal took to react. Animal reaction time is a measurement of animal resistance to pain and is used to measure efficacy of analgesics. 

The plate is designed to be very simple to use at very fast to reach the set temperature (as example From ambient to 4°C, the most used threhold value, it takes less than 10 minutes, and from 4°C to 65°C it takes only 5 minutes) . Metrology wise, is accurate to less than 0,5°C (EEC metrology standard) and perfectly constant in the animal holder system. The preset temperature will not change for more than 0,1°C when a 400g rat is placed on the plate, and return to the set temperature is almost immediate.

 In addition, the instrument can be adjusted to be used for "TEMPERATURE RAMPS" , predefined by the user, this feature is mainly used for studies with telemetry implants. In addition to displaying the reaction time, the Cold/Hot Plate Analgesia Meter is capable of sending the same information via USB interface to a computer. 

The operator can start and stop the timer with the front panel start/stop switch or with the included footswitch, which allows "hands-free" operation.

Specs

Temperature range -4°C to 55°C (in 20°C to 25°C ambient environment, 50% RH)
Temperature Accuracy ±0,5°C
Temperature uniformity on plate ±0,5°C
Power requirements 110V/220V automatic, 100W
Plate Dimensions 165 x 165 mm
Control unit dimensions 305 x 280 x 158 mm
Weight 6,5kg

Publications

  • Jiménez-Aranda A et al. (2013) Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats. Journal of Pineal Research. Volume 55, Issue 4, pages 416–423 (rat, Spain, USA)
  • Chen WH et al. (2012) Attenuation of TRPV1 and TRPV4 Expression and Function in Mouse Inflammatory Pain Models Using Electroacupuncture. Evidence-Based Complementary and Alternative Medicine. (mouse, Taiwan)
  • Jungwirth U et al. (2012) Anticancer Activity of Methyl-Substituted Oxaliplatin Analogs. Molecular Pharmacology vol. 81 no. 5 719-728. (Austria)
  • Tappe-Theodor A et al. (2012) Gαq/11 signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization. PAIN, Volume 153, Issue 1, Pages 184–196. (mouse, Germany, UK)
  • Charlet A et al. (2011) Poincaré plot descriptors of heart rate variability as markers of persistent pain expression in freely moving rats. Physiology & Behavior, Volume 104, Issue 5, Pages 694–701. (rat, France)
  • Favereaux A et al. (2011) Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain. The EMBO Journal (2011) 30, 3830 – 3841. (rat, France, Egypt)
  • Thibault K et al. (2011) Characterisation of sensory abnormalities observed in an animal model of multiple sclerosis: A behavioural and pharmacological study. European Journal of Pain Volume 15, Issue 3, Pages 231.e1–231.e16. (rat, France)
  • Stosser S et al. (2010) Dissecting the functional significance of endothelin A receptors in peripheral nociceptors in vivo via conditional gene deletion. PAIN, Volume 148, Issue 2, Pages 206–214. (mouse, Germany, USA)
  • Noel J et al. (2009) The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception. EMBO J. 28(9):1308-1318. (mouse, France)
  • Yalcin I et al. (2009) Differentiating Thermal Allodynia and Hyperalgesia Using Dynamic Hot and Cold Plate in Rodents. The Journal of pain. 10(7):767-773. (mouse, rat, France)

 

How to order

LE7420

76-0112

Hot/Cold Plate including BSRamp Software

How to order

Please contact our local delegates or contact us directly for receiving a quote.

 

Key features

  • Unmatched temperature stability and control for both heat and cold
  • Fast reach to set temperatures
  • Homogeneous temperature surface
  • Practical foot switch timing operation
  • BSRamp software will allow the user to define temperature ramps (slope in °C/min, start and end points) and store results

 

 
 
 
 
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