HOT PLATE

For evaluating thermal pain sensitivity

Description
Key features
Specs
How to order
Publications

Description

The LE7406 Hot Plate performs rapid and precise screening of analgesic drug properties on small-laboratory animals according to the ‘hot-plate test’. 

In the LE7406 Hot Plate, a thick aluminium plate (10 mm) provides a high temperature stability and even surface distribution. The plate temperature can be held at a set point between 45 and 62°C (± 0.1ºC) by multiple proportional feedback circuits that minimize overshoot. A built-in timer activated by an external foot switch allows precise measurement of reaction time (0.1 sec precision). A remote foot-switch controls the test start/stop allowing rapid hands-free experiments. The operator can read the animal reaction time from the display or from a PC computer using the SEDACOM software. 

The optional SEDACOM software (new version 2.0 available) can be used and represents an easy and convenient way to visualize and export the data (Trial number, plate temperature, reaction time etc.) on a computer for further analysis.

 

Specs

Base Dimensions 200 (W) x 300 (D) x 110 (H) mm
Plate Dimensions 200 (D) mm
Cylinder Dimensions 200 (D) x 250 (H) mm
Operating Temperature 45 to 62 degrees Celsius; 0,1 steps
Reaction time 3 digits, 0,01 secs. increment
Material Composition Clear methacrylate (animal holder), aluminium (plate)
Maximum number of stations 1 per computer (multiple set-ups also available under request)
Power Requirements 110V or 220V, 50/60Hz
Certifications CE Compliant

Publications

  • Bernáldez J et al. (2013) A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits CaV2.2 Channels and Displays an Anti-Nociceptive Activity. Mar. Drugs 2013, 11(4), 1188-1202. (rat, Mexico)
  • Juárez-Reyes K et al. (2013) Antinociceptive activity of Ligusticum porteri preparations and compounds. Pharm Biol. In press (mouse, Mexico)
  • Meziane H et al. (2013) The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord. PeerJ. 2013 Aug 29;1:e142. (mouse, France)
  • Mohammed W et al. (2013) Comparison of tolerance to morphine-induced respiratory and analgesic effects in mice. Toxicology Letters, Volume 217, Issue 3, Pages 251–259 (mouse, France)
  • Nowoczyn M et al. (2013) Remifentanil produces cross-desensitization and tolerance with morphine on the mu-opioid receptor. Neuropharmacology, Volume 73, Pages 368–379. (France)
  • QuintansJúnior LJ et al. (2013) β-Cyclodextrin-complexed (−)-linalool produces antinociceptive effect superior to that of (−)-linalool in experimental pain protocols. Issue Basic & Clinical Pharmacology & Toxicology, Volume 113, Issue 3, pages 167–172. (rat, Brazil)
  • Santos CCMP et al. (2013) Antinociceptive and Antioxidant Activities of Phytol In Vivo and In Vitro Models. Neuroscience Journal, Volume 2013, Article ID 949452, 9 pages (mouse, Brazil)
  • Weibel R et al. (2013) Mu Opioid Receptors on Primary Afferent Nav1.8 Neurons Contribute to Opiate-Induced Analgesia: Insight from Conditional Knockout Mice. PLoS One.;8(9):e74706. (mouse, France)
  • Wu Y et al. (2013) Synergistic antinociception of propofol–alfentanil combination in mice. Pharmacology Biochemistry and Behavior. In Press (mouse, China)
  • Brenchat A et al. (2012) Assessment of 5-HT7 Receptor Agonists Selectivity Using Nociceptive and Thermoregulation Tests in Knockout versus Wild-Type Mice. Advances in Pharmacological Sciences Volume 2012 (2012), Article ID 312041 (mouse, Spain)
  • Elhabazi K et al. (2012) Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments. British Journal of Pharmacology, Volume 165, Issue 2, pages 424–435. (mouse, France)
  • El-Azab MF et al. (2012) Influence of calcium channel blockers on anticonvulsant and antinociceptive activities of valproic acid in pentylenetetrazole-kindled mice. Pharmacol Rep. 2012;64(2):305-14. (mouse, Egypt)
  • Harnández-Ortega M et al. (2012) Antioxidant, Antinociceptive, and Anti-Inflammatory Effects of Carotenoids Extracted from Dried Pepper (Capsicum annuum L.). Journal of Biomedicine and Biotechnology, Volume 2012 (2012), Article ID 524019, 10 pages. (Mexico)
  • Lee YK et al. (2012) Decreased pain responses of C–C chemokine receptor 5 knockout mice to chemical or inflammatory stimuli. Neuropharmacology, Volume 67, April 2013, Pages 57–65 (mouse, Republic of Korea).
  • Parvathy SS et al, (2012) Matrix Metalloproteinase Inhibitor COL-3 Prevents the Development of Paclitaxel-Induced Hyperalgesia in Mice. Medical Principles and Practice. Vol. 22, No. 1. (mouse, Kuwait)
  • Yalcin et al. (2011) Nociceptive thresholds are controlled through spinal β2-subunit-containing nicotinic acetylcholine receptors. PAIN, Volume 152, Issue 9, Pages 2131–2137. (mouse, France, USA)
  • Abu-Ghefreh A et al. (2010) Enhancement of antinociception by coadminstration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis. BMC Musculoskelet Disord. 2010 Dec 1;11:276. (mouse, Kuwait)
  • Ala’a A et al. (2010) Enhancement of antinociception by coadminstration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis. BMC Musculoskelet Disord. 2010 Dec 1;11:276. (mouse, Kuwait)
  • Quitao NLM et al. (2010) N-Antipyrine-3, 4-Dichloromaleimide, an Effective Cyclic Imide for the Treatment of Chronic Pain: The Role of the Glutamatergic System. Anesthesia & Analgesia. 110(3):942-950. (mice, Brazil)
  • Puentes B et al. (2009) Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury. Pain. 145(3):294-303. (mouse, Spain)
  • Viosca J et al. (2009) Germline expression of H-RasG12V causes neurological deficits associated to Costello syndrome. Genes, Brain Behav. 8(1):60-71. (mouse, Spain)
  • Yamamoto T et al. (2009) Intracerebroventricular administration of 26RFa produces an analgesic effect in the rat formalin test. Peptides, Volume 30, Issue 9, September 2009, Pages 1683–1688. (rat, Japan)
  • Charlet A et al. (2008) Fast non-genomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms. PAIN, Volume 139, Issue 3, Pages 603–609. (rat, France)
  • Deval E et al. (2008) ASIC3, a sensor of acidic and primary inflammatory pain. The EMBO Journal (2008) 27, 3047 – 3055. (rat, France)
  • Luvisetto S et al. (2008) Enhancement of anxiety, facilitation of avoidance behavior, and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D. Neuroscience. 155(3):585-596 (mouse, USA)
  • Reiss D et al. (2008) Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: Comparison to morphine. European Journal of Pharmacology, Volume 579, Issues 1–3, Pages 141–148. (mouse, France)
  • Sudo RT et al. (2008) The Antinociceptive Activity of a New alpha-2 Adrenoceptor Agonist (PT-31) in Mice. Anesthesiology 2007; 107: A1455. (Mouse, Brazil)
  • Meziane H et al. (2007) Estrous cycle effects on behavior of C57BL/6J and BALB/cByJ female mice: implications for phenotyping strategies. Genes, Brain and Behavior, Volume 6, Issue 2, pages 192–200. (mouse, France)
  • Beyreuther B et al. (2006) Antinociceptive efficacy of lacosamide in a rat model for painful diabetic neuropathy. European Journal of Pharmacology, Volume 539, Issues 1–2, Pages 64–70. (rat, France)
  • Camarasa J, Pubill D, Escubedo E (2006) Association of caffeine to MDMA does not increase antinociception by potentiates adverse effects of this recreational drug. Brain Res. 1111:72-82. (mouse, Spain)
  • Grillet N et al. (2005) Generation and characterization of Rgs4 mutant mice. Mol. Cell. Biol. 25(10): 4221-4228. (mice, France)
  • Kim EJ et al. (2005) Safety pharmacology of sibutramine mesylate, an anti-obesity drug. Hum. Exp. Toxicol. 24(3): 109-119. (Rat, South Korea)
  • Feria MM et al. (2003) Coexistence of Two Distinct Diurnal Rhythms in Latency of Licking and Jumping Responses in Mice Hot Plate Tests. Biological Rhythm Res. 29(3):260 – 271 (Mouse, Spain)
  • Shaheen HM et al. (2000) Effect of Psidium guajava leaves on some aspects of the central nervous system in mice. Phytotherapy Res. 14(2):107-111 (Mouse, United Arab Emirates)

 

How to order

CONTROL UNIT

LE7406

76-0113

 

Hot-Plate thermal analgesymeter including certificate of calibration and footswitch (SeDaCom Software to be purchased separately)

  

BASIC DATA TRANSFER 

SEDACOM V2.0

76-0406

SeDaCom V2.0 software for data transfer to a computer

CONRS232USB

76-0608

SeDaCom accessory - RS232/USB adapter

LE7000

76-0114

Thermal Printer

How to order

Please contact our local delegates or contact us directly for receiving a quote.

 

Key features

  • Digital set point
  • Built-in electronic timer
  • Foot switch timing operation
  • New optional Data Transfer software SEDACOM 2.0

 

Related tests

Hot Plate test

 
 
 
 
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