CAJA DE EVITACIÓN PASIVA COMPACTA – Passive avoidance

Para la evaluación de la memoria en roedores

Descripción
Puntos clave
Especs.
Como pedirlo
Publicaciones

Descripción

Passive avoidance is fear-motivated tests classically used to assess short-term or long-term memory on small laboratory animals (rat, mice). 

Basically, passive avoidance working protocols involve timing of transitions, i.e. time that the animal takes to move from the white compartment to the black one after a conditioning session -in which the entry into the black compartment is punished with a mild inescapable electrical shock- is carried out.

The Panlab passive avoidance box (LE870/872) is defined by a large white illuminated compartment and a small black dark compartment separated by a guillotine gate. The animal position is detected by using high sensitivity weight transducers providing higher effective and reliable detection of animal responses (zones entries) than systems based on photocells beams or on grid floor displacements.

Panlab Passive Avoidance boxes are controlled by the ShutAvoid software, allowing to run passive avoidance experiments in several boxes simultaneously. It is not necessary the use of PCI board installed into the PC. The link is carried out by one only cable from one Box to the other. The first Box is connected to PC or Laptop through a RS232/USB communcation.

The passive avoidance test can also be conducted in a shuttle box for both the active and passive avoidance tests.

 

Especs.

Mouse box dimensions 250 (W) x 250 (D) x 240 (H) mm White compartment; 195 x 108 x 120 mm Black compartment
Rat box dimensions 310 (W) x 310 (D) x 240 (H) mm White compartment; 195 x 108 x 120 mm Black compartment
Minimum weight detected 10 grams (Mouse Box); 40 grams (Rat Box)
Material Composition Methacrylate, aluminium, stainless steel
Maximum number of stations 8 stations connected to a PC
Connection of several units to PC No PC card is required (USB communication). One cable connects all units to the PC.
Certifications CE Compliant
Power Supply 110V/220V, 50/60Hz

Publicaciones

  • Klusa V et al. (2013) Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats. Pharmacology Biochemistry and Behavior, Volume 106, May 2013, Pages 68–76. (rat, Latvia)
  • Leger et al. (2012) Environmental enrichment improves recent but not remote memory in association with a modified brain metabolic activation profile in adult mice. Behavioural Brain Research, Volume 228, Issue 1, 1 March 2012, Pages 22–29. (mouse, France)
  • Mòdol L et al. (2012) Alteration of neonatal Allopregnanolone levels affects exploration, anxiety, aversive learning and adult behavioural response to intrahippocampal neurosteroids. Behavioural Brain Research, Volume 241, 15 March 2013, Pages 96–104. (rat, Spain)
  • Shi Y et al. (2012) Neurobehavioral Assessments of Focal Cerebral Ischemia: Cognitive Deficit. Animal Models of Acute Neurological Injuries II, Springer Protocols Handbooks 2012, pp 157-162. (rodent, USA)
  • Mòdol L et al. (2011) Neurosteroids infusion into the CA1 hippocampal region on exploration, anxiety-like behaviour and aversive learning. Behavioural Brain Research, Volume 222, Issue 1, 12 September 2011, Pages 223–229. (rat, Spain)
  • Bouet V et al. (2010) Predicting sensorimotor and memory deficits after neonatal ischemic stroke with reperfusion in the rat. Behavioural Brain Research, Volume 212, Issue 1, 1 September 2010, Pages 56–63. (rat, France)
  • Andoh T et al. (2009) Influences of molar loss of rat on learning and memory. Journal of Prosthodontic Research,Volume 53, Issue 4, October 2009, Pages 155–160. (rat, Japan)
  • Bazin MA et al. (2009) The effects of DHEA, 3β-hydroxy-5α-androstane-6, 17-dione, and 7-amino-DHEA analogues on short term and long term memory in the mouse. Steroids, Volume 74, Issue 12, 4 November 2009, Pages 931–937. (mouse, France)
  • Cuhna C et al. (2009) Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments. Neurobiology Disease. 33(3):358-368. (mouse, Italy)
  • Ferret T et al. (2009) Behavioral deficits after distal focal cerebral ischemia in mice: Usefulness of adhesive removal test. Behavioral Neuroscience, Vol 123(1), Feb 2009, 224-230. (mouse, France)
  • Matsui N et al. (2009) Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice. Brain Research, Volume 1305, 11 December 2009, Pages 108–117. (mouse, Japan)
  • Méndez M et al. (2009) Associative learning deficit in two experimental models of hepatic encephalopathy. Behavioural Brain Research, Volume 198, Issue 2, 17 March 2009, Pages 346–351. (rat, Spain)
  • Monleon S et al. (2009) Effects of oxotremorine and physostigmine on the inhibitory avoidance impairment produced by amitriptyline in male and female mice. Behav Brain Res. 2009 Dec 28;205(2):367-71. (mouse, Spain)
  • Esneault E et al. (2008) Combined therapeutic strategy using erythropoietin and mesenchymal stem cells potentiates neurogenesis after transient focal cerebral ischemia in rats. Journal of Cerebral Blood Flow & Metabolism (2008) 28, 1552–1563. (rat, France)
  • Matsuno A et al. (2008) Hippocampal glutamate release on learning and memory in teeth-loss rats. Prothodont. Res. Pract. 7: 71-77. (rat, Japan)
  • Millan MAJ et al. (2008) S33138 (N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1] benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenyl-acetamide), a Preferential Dopamine D3 versus D2 Receptor Antagonist and Potential Antipsychotic Agent: III. Actions in Models of Therapeutic Activity and Induction of Side Effects. JPET March 2008 vol. 324 no. 3 1212-1226. (rat, France)
  • Martín-García E et al. (2008) Neonatal finasteride induces anxiogenic-like profile and deteriorates passive avoidance in adulthood after intrahippocampal neurosteroid administration. Neurosci. 154(4):1497-1505. (rat, Spain)
  • Rueda N et al (2008) Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down síndrome. Behav. Brain Res. 188(2):355-367 (Mouse, Spain)
  • Tramullas M et al (2008) Facilitation of avoidance behaviour in mice chronically treated with heroin or methadone. Res. Rep. 189(2):332-340 (Mouse, Spain)
  • Bouet V et al. (2007) Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse. Exp. Neurol. 203(2):555-567 (Mouse, France)
  • Haelewyn B et al. (2007) Long-term evaluation of sensorimotor and mnesic behaviour following striatal NMDA-induced unilateral excitotoxic lesion in the mouse. Behav. Brain Res. 178(2):245-243 (Mouse, France)
  • Millan M et al. (2007) A preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent. III. Actions in models of therapeutic activity and induction of side-effects. J. Pharmacol. Exp. Ther. (rat, France)
  • Xunhe J et al. (2007) Post-ischemic continuous administration of galantamine attenuates cognitive deficits and hippocampal neurons loss after transient global ischemia in gerbils. Neuroscience Letters, Volume 416, Issue 1, 6 April 2007, Pages 92–95. (gerbils, China)
  • Lelong-Boulouard V et al. (2006) Interactions of buprenorphine and dipotassium clorazepate on anxiety and memory functions in the mouse. Drug and Alcohol Dependence, Volume 85, Issue 2, 8 November 2006, Pages 103–113. (mouse, France)
  • Garcia-Calatayud S et al. (2005) Brain Docosahexaenoic Acid Status and Learning in Young Rats Submitted to Dietary Long-Chain Polyunsaturated Fatty Acid Deficiency and Supplementation Limited to Lactation Pediatric Research 57:719-723 (rat, Spain)
  • Trabace L et al. (2000) Biochemical and Neurobehavioral Profile of CHF2819, a Novel, Orally Active Acetylcholinesterase Inhibitor for Alzheimer's Disease JPET 294 (1): 187-194 (rat, Italy)
  • Barrionuevo M et al. (2000) Serotoninergic deficits and impaired passive-avoidance learning in rats by MDEA: a comparison with MDMA. Pharmacol. Biochem. Behav. 65(2): 233-240. (rat, Spain)
  • Artaiz I et al. (1995) The pharmacology of VA21B7: an atypical 5-HT3 receptor antagonist with anxiolytic-like properties in animal models. Psychopharmacol. 117(2): 137-148. (mouse, Spain)
  • Faiman CP et al. (1994) Differential effects of compounds that act at strychnine-insensitive glycine receptors in a punishment procedure. J. Pharmacol. Exp.Ther. 270(2): 528-533. (mouse, Spain)

 

Como pedirlo

PASSIVE AVOIDANCE BOXES

LE870

76-0199

Passive Avoidance Cage for Rat

LE872

76-0200

Passive Avoidance Cage for Mice

 

SHUTAVOID SOFTWARE OPTION 

SHUTAVOID

76-0202

Software to control up to 8 Active/Passive boxes.

LE10026

76-0159

Shock generator with scrambler. 0-2 mA output (1 per box)

Cómo pedir una orferta

Contacta nuestro distribuidor el más cercano o contáctanos directamente para recibir una oferta.

 

Puntos clave

  • Weight transducer technology for accurate animal detection
  • Very precise and stable intensity of shock delivered into the black compartment
  • No PC card is required (USB coms).
  • Safety System which guarantees that the shock intensity received by the animal is always the same value independently of the grid bars treaded.

 

 
 
 
 
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