TAIL FLICK METER

for evaluating thermal analgesia or hyperalgesia in rodents

Description
Key features
Specs
How to order
Publications

Description

The LE7106 Tail-flick Meter consists of a Stimulation Unit (containing the halogen lamp for the heat stimulus) and an electronic Control Unit. The system can be used for rats and mice of different sizes. The animals are placed with its tail protruding within a restraining tube on the platform of the Stimulus Unit. The animal’s tail is positioned on a slot of adjustable width equipped with a groove that guarantees a correct placement of the rodent’s tail. A remote foot-switch controls the test start/stop allowing rapid hands-free experiments. 

A photo beam detects the tail flick and the latency is automatically presented on a digital display on the Control Unit. Measurements of reaction time are given with a 0.01 s precision. A cut-off time is set to avoid tissue damage (by default: 20 s). The precise control of the heat stimulus and the groove system ensure optimum repeatability and reliability of results.

The optional SeDacom software (new version 2.0 available) can be used and represents an easy and convenient way to visualize and export the data on a computer for further analysis.

 

Specs

Control Unit Dimensions 350 (W) x 350 (D) x 130 (H)
Stimulation Unit Dimensions 400 (W) x 140 (D) x 155 (H)
Power Supply 110V/220V, 50/60Hz
Material Composition Methacrylate, halogen lamp
Maximum number of stations 1 per computer (multiple set-ups also available under request)
Certifications CE Compliant

Publications

  • Bhalla S et al. (2013) Centhaquin antinociception in mice is mediated by α2A- and α2B- but not α2C-adrenoceptors. Eur J Pharmacol. 2013 Sep 5;715(1-3):328-36. (mouse, USA)
  • Bouchra M et a. (2013) Analgesic, anti-inflammatory and antidepressant activities of triterpene from meiocarpidium leìdotum (annonaceae) bark. International Journal of Phytopharmacology, 4(2), 2013, 133-140. (mouse, Morocco)
  • Vidal-Torres A et al. (2013) Sigma-1 receptor antagonism as opioid adjuvant strategy: enhancement of opioid antinociception without increasing adverse effects. Eur J Pharmacol. 2013 Jul 5;711(1-3):63-72. (Esteve, mouse, Spain)
  • Bhalla S et al. (2012) Potentiation of oxycodone antinociception in mice by agmatine and BMS182874 via an imidazoline I2 receptor-mediated mechanism. Pharmacol Biochem Behav. 2013 Jan;103(3):550-60. (mouse, USA)
  • Caceres A et al. (2012) Ethnobotanical, pharmacognostical, pharmacological and phytochemical studies on Smilax domingensis in Guatemala. Rev. bras. farmacogn. vol.22 no.2 Curitiba Mar./Apr. (Guatemala, Argentina)
  • Elhabazi K et al. (2012) Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments. Br J Pharmacol. 2012 Jan;165(2):424-35. (mouse, France)
  • Lee YK et al. (2012) Decreased pain responses of CC chemokine receptor 5 knockout mice to chemical or inflammatory stimuli. Neuropharmacology Volume 67, April 2013, Pages 57–65, (mouse, Korea)
  • Nita LE et al. (2012) Indomethacin uptake into poly(2-hydroxyethyl methacrylate-co-3,9-divinyl-2,4,8,10-tetraoxaspiro [5.5]-undecane) network: In vitro and in vivo controlled release study. Int J Pharm. 2012 Apr 15;426(1-2):90-9. (Romania)
  • Saltan Çitoğlu G et al. (2012) Evaluation of analgesic, anti-inflammatory and hepatoprotective effects of lycorine from Sternbergia fisheriana (Herbert) Rupr. Fitoterapia. 2012 Jan;83(1):81-7. (mouse, Turkey)
  • Xu F et al. (2012) The neurotoxicity of intrathecal lidocaine is enhanced in postpartum compared to virgin rats. Fundam Clin Pharmacol. 2013 Aug;27(4):427-33. (rat, China)
  • Bhalla S et al. (2011) Determination of α(2)-adrenoceptor and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by agmatine and BMS182874. Eur J Pharmacol. 2011 Jan 25;651(1-3):109-21. (mouse, USA)
  • Nozaki C et al. (2011) Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit. Nat Neurosci. 2011 Jul 3;14(8):1017-22. (mouse, France)
  • Pratte M et al. (2011) Progressive motor and respiratory metabolism deficits in post-weaning Mecp2-null male mice. Behav Brain Res. 2011 Jan 1;216(1):313-20. (mouse, France)
  • Bhalla S et al. (2010) Effect of endothelin-A receptor antagonist on mu, delta and kappa opioid receptor-mediated antinociception in mice. Eur J Pharmacol. 2010 Jun 10;635(1-3):62-71. (mouse, USA)
  • Yun MH et al. (2010) Pharmacokinetic-Pharmacodynamic modeling of the analgesic effect of bupredermTM, in mice. Health, 2, 824-831. (mouse, Korea)
  • Altun ML et al. (2009) Antinociceptive and anti-inflammatory activities of Viburnum opulus. Pharmaceutical Biology Vol. 47, No. 7 , Pages 653-658. (rat, mouse, Turkey)
  • Gulati et al. (2009) Determination of Adrenergic and Imidazoline Receptor Involvement in Augmentation of Morphine and Oxycodone Analgesia by Clonidine and BMS182874. Pharmacology. 83:45-58. (rat, USA)
  • Puente B et al. (2009) Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury. Pain. 2009 Oct;145(3):294-303. (mouse, Spain).
  • Tekin M et al. (2009) Investigation of Acute Toxicity, Anti-inflammatory, and Analgesic Effect of Urtica dioica L. Pharmacologyonline 1: 1210-1215 (mouse, Turkey)
  • Xu F et al. (2009) An improved method for protecting and fixing the lumbar catheters placed in the spinal subarachnoid space of rats. J Neurosci Methods. 2009 Oct 15;183(2):114-8. (rat, China)
  • Bakir B et al. (2008) Investigation of the anti-inflammatory and analgesic activities of-caryophyllene. International Journal of Essential Oil Therapeutics, Volume 2, Number 1, March 2008 , pp. 41-44(4) (Turkey)
  • Gulati A et al. (2008) Determination of adrenergic and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by clonidine and BMS182874. Pharmacology. 2009;83(1):45-58. (rat, USA)
  • Him A et al. (2008) Antinociceptive activity of alpha-pinene and fenchone. Pharmacologyonline 3: 363-369 (mouse, Turkey)
  • Park I et al (2008) Buprederm™, a New Transdermal Delivery System of Buprenorphine: Pharmacokinetic, Efficacy and Skin Irritancy Studies. Pharm. Res. 25(5):1052-1062 (mouse, Korea)
  • Parker AG et al. (2007) Antinociceptive effects of the aqueous extract of Brugmansia suaveolens flowers in mice. Biol. Res. For Nursing. 8(3): 234-239. (mouse, Brazil)
  • Yilmaz BS et al. (2007) Antinociceptive and Anti-inflammatory Activities of Viburnum lantana. Pharmaceutical Biology Vol. 45, No. 3 , Pages 241-245. (rat, mouse, Turkey)
  • Andriambeloson E et al. (2006) Interleukin-6 attenuates the development of experimental diabetes-related neuropathy. Neuropathology. 26(1): 32-42. (rat, France)
  • Andrieu D et al. (2006) Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death. BMC Dev Biol. 6:56. (mouse, France)
  • Yilmaz BS et al. (2006) Analgesic and hepatotoxic effects of Ononis spinosa L. Phytotherapy Research20(6):500-503. (Turkey)
  • Yilmaz BS et al. (2006) Antinociceptive and Anti-inflammatory Activities of Ballota inaequidens. Pharmaceutical Biology Vol. 44, No. 8 , Pages 636-641 (mouse, rat, Turkey)
  • Cendán CM et al. (2005) Antinociceptive effects of haloperidol and its metabolites in the formalin test in mice. Psychopharmacol. 182(4): 485-493. (mouse. Spain)
  • Ozturk G et al. (2005) Effect of leukemia inhibitory factor in experimental cisplatin neuropathy in mice. Cytokine. 2005 Jan 7;29(1):31-41. (mouse, Turkey)
  • Grillet N et al. (2005) Generation and characterization of Rgs4 mutant mice. Mol. Cell. Biol. 25(10): 4221-4228. (mouse, France)
  • Moncada A et al. (2005) Inhibitors of serine/threonine protein phosphatases antagonize the antinociception induced by agonists of alpha 2 adrenoceptors and GABAB but not kappa-opioid receptors in the tail flick test in mice. Pain 114(1-2): 212-220. (mouse, Spain)
  • Garrido MJ et al. (2003) Pharmacokinetic/Pharmacodynamic Modeling of the Antinociceptive Effects of (+)-Tramadol in the Rat: Role of Cytochrome P450 2D Activity. JPET 305(2): 710-718. (rat, Spain)
  • Masocha W et al. (2003). Role of Na+,K+-ATPase in Morphine-Induced Antinociception. J. Pharmacol. Exp. Ther. 306:1122-1128. (mouse, Spain)
  • Martin M et al. (2003) Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones. Eur. J. Neurosci. 17(4): 701 (mouse, France, Spain)
  • Moncada A et al. (2003) Effects of serine/threonine protein phosphatase inhibitors on morphine-induced antinociception in the tail flick test in mice. Eur. J. Pharmacol. 465:53-60. (mouse, Spain)
  • Garrido MJ et al. (2000) Modeling of the In Vivo Antinociceptive interaction between an opioid agonist, (+)-O-desmethyltramadol, and a monoamine reuptake inhibitor, (-)-O-desmethyltramadol, in rats. J. Pharmacol. Exp. Ther. 295(1): 352-359. (rat, Spain)
  • Kew JN et al. (2000) Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site. J. Neurosci. 20(11): 4037-4049. (mouse, Switzerland)
  • Valle M et al. (2000) Pharmacokinetic-Pharmacodynamic Modeling of the Antinociceptive Effects of Main Active Metabolites of Tramadol, (+)-O-Desmethyltramadol and (-)-O-Desmethyltramadol, in Rats. J. Pharmacol. Exp. Ther. 293(2): 646-653. (rat, Spain)
  • Garrido MJ, Valle, M, Calvo R, Trocóniz IF (1999) Altered Plasma and Brain Disposition and Pharmacodynamics of Methadone in Abstinent Rats. J. Pharmacol. Exp. Ther.  288 (1): 179-187. (rat, Spain)
  • Martinez-Cue C et al. (1999) A murine model for Down syndrome shows reduced responsiveness to pain. Neuroreport 10(5): 1119-1122. (mouse, Spain).
  • Ocana M, Barrios M, Baeyens JM (1996) Cromakalin differentially enhances antinociception induced by agonists of alpha (2) adrenoceptors, gamma-aminibutyric acid (B), mu and kappa opioid receptors.  J. Pharmacol.Exp. Ther. 276: 1136-1142 (mouse, Spain)
  • Ocaña M et al. (1994) Role of ATP-sensitive K+ channels in antinociception induced by R-PIA, an adenosine A1 receptor agonist. Naunyn-Schmiedeberg’s Arch. Pharmacol. 350(1): 57-62. (mouse, Spain)
  • Dierssen M, Flórez J, Hurlé MA (1990) Calcium channel modulation by dihydropyridines modifies sufentanil-induced antinociception in acute and tolerant conditions- Naunyn-Schmiedeberg’s Arch. Pharmacol. 342(5): 1432-1912. (rat, Spain)

 

How to order

CONTROL UNIT & STIMULUS

LE7106

76-0293

Tail Flick heat beam meter (includes the pedal). The restrainer has to be ordered separately.

 

RESTRAINERS

LE5016

76-0183

Mice restrainer (small animals).

LE5018

76-0184

Mice restrainer (large animals).

LE5020

76-0185

Rat restrainer 150 gr.

LE5022

76-0186

Rat restrainer 250 gr.

LE5024

76-0187

Rat restrainer 400 gr.

LE5025

76-0188

Rat restrainer 500 gr.

 

TAIL TEMPERATURE OPTION

LE7106T

76-0294

Tail-Temperature recorder.

 

DATA TRANSFER & SOFTWARE 

SEDACOM V2.0

76-0406

SeDaCom V2.0 software for data transfer to a computer.

CONRS232USB

76-0608

SeDaCom accessory - RS232/USB adapter.

How to order

Please contact our local delegates or contact us directly for receiving a quote.

 

Key features

  • Digital display
  • Precise intensity light beam adjustment
  • Optimal detection due to perfect alignment of heat stimulus and photo beam
  • A light beam shows the point on which the heat source will focus
  • Manual and remote trigger
  • Groove for correct tail placement
  • Automatic cut-off
  • New optional Data Transfer software SEDACOM 2.0

 

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