PLETHYSMOMETER

for evaluating paw volume during inflammation in rodents

Description
Key features
Specs
How to order
Publications

Description

The Digital Water Plethysmometer is designed to provide a highly useful tool in the measurement of small volume changes. This test is typically used to follow the evolution of the inflammatory response experimentally induced in rodents and to screen potential anti-inflammatory or anti-oedema properties of pharmacological substances.

Basically, the volume transducer is formed by two Perspex tubes interconnected and filled with a conductive solution and a platinum electrode for each chamber. All the system is supported by a stand (included) that can be placed over the control unit.

The water displacement produced by the immersion of the animal paw in the measuring tube is reflected into the second tube, inducing a change in the conductance between the two platinum electrodes. The Plethysmometer Control Unit detects the conductance changes and generates an output signal to the digital display indicating the volume displacement measured (0.01 ml resolution). The current value remains in the digital display until a new trial starts. The Control Unit is automatically zeroed between successive readings, thus making intermediate adjustments unnecessary. 

A remote foot-switch allowing rapid hands-free experiments can be used to set control the end point of the measurement.

The optional SeDacom software (new version 2.0 available) can be used and represents an easy and convenient way to visualize and export the data on a computer for further analysis.

 

Specs

Control Unit Dimensions 280 (W) x 280 (D) x 110 (H)
Stimulation Unit Dimensions 230 (W) x 220 (D) x 300 (H)
Power Supply 220V/110V, 50/60Hz
Starting By panel key or pedal switch
Resolution 3 digits, 0,01 steps
Material Composition Clear methacrylate (cell), satinless steel (stand), platinum (electrode)
Maximum number of stations 1 per computer (multiple set-ups also available under request)
Certifications CE Compliant
5 ml cell inner diameter 24 mm
3 ml cell inner diameter 20 mm
1 ml cell inner diameter 12 mm

Publications

  • Al.Fararjeh MA et al. (2013) Evaluation of Immunomodulatory Effects of Antiepileptic Drug Phenytoin. Jordan Journal of Biological Sciences. Volume 6, Number 4, December, Pages 328 – 333. (mouse, Jordan)
  • Muhammad N et al. (2013) Analgesic and anti-inflammatory profile of n-hexane fraction of viola betonicifolia. Tropical Journal of Pharmaceutical Research. Vol 11, No 6. (mouse, Pakistan)
  • Nalbantsoy A et al. (2013) Viper venom induced inflammation with Montivipera xanthina (Gray, 1849) and the anti-snake venom activities of Artemisia absinthium L. in rat. Toxicon. 2013 Apr;65:34-40. (rat, Turkey)
  • Pinto NV et al. (2013) Inflammatory and hyperalgesic effects of oxidized multi-walled carbon nanotubes in rats. J Nanosci Nanotechnol. 2013 Aug;13(8):5276-82. (Brazil)
  • Sakat SS et al. (2013) Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model. Inflammation. 2013 Sep 5. In Press (rat, India)
  • Ullah N et al. (2013) Bioisosteric synthesis of nitrogen containing derivatives of salicyl alcohol, their in vivo pharmacological studies with molecular modelling. Medicinal Chemistry Research, October 2013, Volume 22, Issue 10, pp 4677-4684 (Pakistan)
  • Vishwakarma S et al. (2013) Tubastatin, a selective histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects. Int Immunopharmacol. 2013 May;16(1):72-8. (mouse, India)
  • Afzal M et al. (2012) Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum. Fitoterapia. 2012 Jul;83(5):853-8. (mouse, India)
  • Anoside CA et al. (2012) The anti-inflammatory activity of garden egg (Solanum aethiopicum) on egg albumin-induced oedema and granuloma tissue formation in rats. Asian Pac J Trop Med. 2012 Jan;5(1):62-6. (rat, Nigeria)
  • Assreuy AM et al. (2012) Edematogenic activity of a sulfated galactan from the red marine algae Gelidium crinale. Pharm Biol. 2012 Sep;50(9):1194-8. (rat, Brazil)
  • Chawla G et al. (2012) Syntheses and evaluation of anti-inflammatory, analgesic and ulcerogenic activities of 1,3,4-oxadiazole and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives. J Enzyme Inhib Med Chem. 2012 Oct;27(5):658-65. (India)
  • Choi JH et al. (2012) Anti-inflammatory and anti-nociceptive properties of Prunus padus. J Ethnopharmacol. 2012 Nov 21;144(2):379-86. (Korea)
  • Guilhon-Simplicio F et al. (2012) Anti-inflammatory, anti-hyperalgesic, antiplatelet and antiulcer activities of Byrsonima japurensis A. Juss. (Malpighiaceae). J Ethnopharmacol. 2012 Mar 27;140(2):282-6. (rat, Brazil)
  • Ince I et al. (2012) Antioxidant, anti-inflammatory activities and acute toxicity of the polyherbal formulation: Romix®. Pharm Biol. 2012 Jun;50(6):720-6. (rat, Turkey)
  • Lima GM et al. (2012) Phytochemical screening, antinociceptive and anti-inflammatory activities of Chrysopogon zizanioides essential oil. Rev. bras. farmacogn. vol.22 no.2 Curitiba Mar./Apr. (mouse, Brazil)
  • Muhammad N et al. (2012) Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. BMC Complement Altern Med. 2012 May 2;12:59. (mouse, Pakistan)
  • Panday AP et al. (2012) Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines. Inflamm Res. 2012 Apr;61(4):293-304. (rat, India)
  • Pereira LP et al. (2012) Anti-inflammatory polysaccharides of Azadirachta indica seed tegument. Rev. bras. farmacogn. vol.22 no.3 Curitiba May/June (rat, Brazil)
  • Pereira LP et al. (2012) Polysaccharide fractions of Caesalpinia ferrea pods: Potential anti-inflammatory usage. J Ethnopharmacol. 2012 Jan 31;139(2):642-8. (Brazil)
  • Ponte EL et al. (2012) Comparative study of the anti-edematogenic effects of anethole and estragole. Pharmacol Rep. 2012 Jul;64(4):984-90. (mouse, Brazil)
  • Temponi Vdos S et al. (2012) Antinociceptive and Anti-Inflammatory Effects of Ethanol Extract from Vernonia polyanthes Leaves in Rodents. Int J Mol Sci. 2012;13(3):3887-99. (Brazil)
  • Tonk RK et al. (2012) Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents. Eur J Med Chem. 2012 Nov;57:176-84. (India)
  • Barakat N et al. (2011) Enhancement of skin permeation and anti-inflammatory effect of indomethacin using microemulsion. Asian J Pharm 2011;5:141-9. (Saudi Arabia)
  • da Silva G et al. (2011) In vivo anti-inflammatory effect and toxicological screening of Maytenus heterophylla and Maytenus senegalensis extracts. Hum Exp Toxicol. 2011 Jul;30(7):693-700. (mouse, Portugal)
  • da Silva JB et al. (2011) New approaches to clarify antinociceptive and anti-inflammatory effects of the ethanol extract from Vernonia condensata leaves. Int J Mol Sci. 2011;12(12):8993-9008. (Brazil)
  • Goubeia MGS et al. (2011) Antioxidant, antinociceptive, and anti-inflammatory properties of the ethanolic extract of Combretum duarteanum in rodents. Journal of Medicinal Food. November 2011, 14(11): 1389-1396. (mouse, Brazil)
  • Graça JRV et al. (2011) Effect of a crude sulfated polysaccharide from Halymenia floresia (Rhodophyta) on gastrointestinal smooth muscle contractility. Braz. arch. biol. technol. vol.54 no.5 Curitiba Sept./Oct. (rat, Brazil)
  • Jigam AA et al. (2011) In-vivo antimalarial and toxicological evaluation of Chrozophora senegalensis A. Juss (euphorbaceae) extracts. Journal of Applied Pharmaceutical Science 01 (10); 2011: 90-94. (mouse, Nigeria)
  • Melo MS et al. (2011) Anti-infl ammatory and redox-protective activities of citronellal. Biol Res 44: 363-368. (mouse, Brazil)
  • Siquiera RCL et al. (2011) In vivo anti-inflammatory effect of a sulfated polysaccharide isolated from the marine brown algae Lobophora variegata. Pharmaceutical Biology. 49(2):167-174. (rat, Brazil)
  • Sosa-Sequera MC et al. (2011) Kaurenic acid: Evaluation of the in vivo and in vitro antitumor activity on murine melanoma. Indian J Pharmacol. 2011 Nov;43(6):683-8. (mouse, Venezuela)
  • Ustündağ Okur N et al. (2011) Evaluation of skin permeation and anti-inflammatory and analgesic effects of new naproxen microemulsion formulations. Int J Pharm. 2011 Sep 15;416(1):136-44. (rat, Turkey)
  • Abbah J et al. (2010) Pharmacological evidence favouring the use of Nauclea latifolia in malaria ethnopharmacy: effects against nociception, inflammation, and pyrexia in rats and mice. J Ethnopharmacol. 2010 Jan 8;127(1):85-90. (rat, mouse, USA)
  • Bhandari SV et al. (2010) Design, synthesis, and evaluation of anti-inflammatory, analgesic, ulcerogenicity, and nitric oxide releasing studies of novel indomethacin analogs as non-ulcerogenic derivatives. J Enzyme Inhib Med Chem. 2010 Aug;25(4):520-30. (India)
  • De Sousa OV et al. (2010) Antinociceptive and Anti-Inflammatory Activities of the Ethanol Extract of Annona muricata L. Leaves in Animal Models. Int J Mol Sci. 2010 May 6;11(5):2067-78. (Brazil)
  • El-Setouhy DA et al. (2010) Ketorolac trometamol topical formulations: release behaviour, physical characterization, skin permeation, efficacy and gastric safety. J Pharm Pharmacol. 2010 Jan;62(1):25-34. (rat, Egypt)
  • Fagundes LL et al. (2010) Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves. Int J Mol Sci. 2010 Oct 15;11(10):3942-53. (Brazil)
  • Fonseca LC et al. (2010) 7-hydroxyfrullanolide, a sesquiterpene lactone, inhibits pro-inflammatory cytokine production from immune cells and is orally efficacious in animal models of inflammation. Eur J Pharmacol. 2010 Oct 10;644(1-3):220-9. (India)
  • Kale S et al. (2010) Anti-inflammatory effect of petroleum ether extract of Caesalpinia bonduc (L.) Roxb seed kernel in rats using carrageenan-induced paw edema. Int. J. PharmTech Res. 2(1):750-752. (rat, India).
  • Mokale VJ et al. (2010) Synthesis and pharmacological evaluation of novel 1-(2-(benzoyl-substituted-2-phenyl-1H-indol-5-carbony) hydrazinyloxy) vinyl nitrate derivatives as potent non-ulcerogenic, analgesic and anti-inflammatory agents. Med Chem. 2010 Jul;6(4):211-8. (rat, India)
  • Quintans LJ et al. (2010) Antinociceptive and anti-inflammatory effects of Costus spicatus in experimental animals. Pharm Biol. 2010 Oct;48(10):1097-102. (Brazil)
  • Shimoda H eta l. (2010) Anti-Inflammatory Properties of Red Ginger (Zingiber officinale var. Rubra) Extract and Suppression of Nitric Oxide Production by Its Constituents. Journal of Medicinal Food. 13(1): 156-162. (rat, Korea, Japan)
  • Sosa-Sequera MC et al. (2010) Kaurenic acid: An in vivo experimental study of its anti-inflammatory and antipyretic effects. Indian J Pharmacol. 2010 Oct;42(5):293-6. (rat, Venezuela)
  • Bhandari SV et al. (2009) Design, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs. Eur J Med Chem. 2009 Nov;44(11):4622-36. (India)
  • Bignotto L et al. (2009) Anti-inflammatory effect of lycopene on carrageenan-induced paw oedema and hepatic ischaemia–reperfusion in the rat. British Journal of Nutrition 102:126-133 (rat, Brazil)
  • Del Vechio Vieira G et al. (2009) Analgesic and anti-inflammatory properties of essential oil from Ageratum fastigiatum. Braz. arch. biol. technol. vol.52 no.5 Curitiba Sept./Oct. 2009 (rat, Brazil)
  • Gautam M et al. (2009) Immunomodulatory activity of Asparagus racemosus on systemic Th1/Th2 immunity: implications for immunoadjuvant potential. J Ethnopharmacol. 2009 Jan 21;121(2):241-7. (India)
  • Gupta et al. (2009) Anti-arthritic activity of various extracts of Sida rhombifolia aerial parts. Natural Product research: Formerly Natural Product Letters. 23(8):689-695. (rat, India)
  • Ince I et al (2009) Effects of Pinus brutia bark extract and Pycnogenol in a rat model of carrageenan induced inflammation. Phytomedicine. 2009 Dec;16(12):1101-4. (rat, Turkey)
  • Jegede IA et al. (2009) Micromorphological, anti-nociceptive and antiinflammatory investigations of stem bark of Daniellia oliveri. African Journal of Biotechnology Vol 5, No 10 (rat, Nigeria)
  • Shabi MM et al. (2009) C. halicacabum (Linn): investigations on anti-inflammatory and analgesic effect. Bulgarian Journal of Veterinary Medicine (2009), 12, No 3, 171−177. (rat, India)
  • Sujatha K et al. (2009) Synthesis, analgesic and anti-inflammatory activities of bis(indolyl)methanes. Indian Journal of Chemistry. 48B(02):267-272. (rat, India)
  • Bhandari SV et al. (2008) Anti-inflammatory, analgesic, ulcerogenic and nitric oxide releasing activities of some novel non-steroidal ibuprofen analogs in animal models. Pharmacologyonline 2: 572-587. (mouse, India)
  • Karasulu HY et al. (2008) Permeation studies of indomethacin from different emulsions for nasal delivery and their possible anti-inflammatory effects. AAPS PharmSciTech. 2008;9(2):342-8. (rat, Turkey)
  • Sousa OV et al. (2008) Antinociceptive and anti-inflammatory effects of the essential oil from Eremanthus erythropappus leaves. J Pharm Pharmacol. 2008 Jun;60(6):771-7. (mouse, Brazil)
  • Favre-Guilmard C et al. (2008) The novel inhibitor of the heterotrimeric G-protein complex, BIM-46187, elicits anti-hyperalgesic properties and synergizes with morphine. European Journal of Pharmacology. 594(1-3):70-76. (rat, France)
  • Gautam M et al. (2008) Immunomodulatory activity of Asparagus racemosus on systemic Th1/Th2 immunity: Implications for immunoadjuvant potencial. Journal of Ethnopharmacology, 121(2):241-247. (rat, India)
  • Ghangale GR et al. (2008) Evaluation of Aegle marmelos (Bael) for Anti-inflammatory Activity in Rats. The Journal of Bombay Veterinary College. 16(1). (rat, India)
  • Karasulu HY et al. (2008) Permeation Studies of Indomethacin from Different Emulsions for Nasal Delivery and Their Possible Anti-Inflammatory Effects. AAPS PharmSciTech. 9(2): 342-348. (rat, Turkey)
  • Ribeiro IA et al. (2008) Effect of naringin enzymatic hydrolysis towards naringenin on the anti-inflammatory activity of both compounds. Journal of Molecular Catalysis B: Enzymatic. 52-53:13-18. (rat, Portugal)
  • Adzu B et al. (2007) Studies on the use of Zizyphus spina-christi against pain in rats and mice. African Journal of Biotechnology, 6(11):1317-1324. (rat, Nigeria)
  • Bhandari SV et al. (2007) Design, Synthesis and Evaluation of Antiinflammatory, Analgesic and Ulcerogenicity studies of Novel S-Substituted phenacyl-1,3,4-oxadiazole-2-thiol and Schiff bases of Diclofenac acid as Nonulcerogenic Derivatives. Bioorganic & Medicinal Chemistry, 16(4):1822-1831. (rat, India)
  • Karabay-Yavasoglu N et al. (2007) Antinociceptive and Anti-inflammatory Activities and Acute Toxicity of Achillea nobilis subsp. neilreichii Extract in Mice and Rats. Pharm. Biol. 45(2):162-168 (rat, mouse, Turkey)
  • Raut MK et al. (2007) Anti-inflammatory, analgesic, ulcerogenic activities of some new non-acidic diclofenac and 1,3,4-oxadiazole derivatives in animal models. Pharmacologyonline. 2:172-186. (mouse, India)
  • Bani S et al (2006) Suppression of lymphocyte activity by lupeol isolated from crataeva religiosa. Phytotherapy research 20(4): 279-287 (mouse, India)
  • Romero-Sandoval EA et al (2006) Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. I. Effects after oral administration. Br. J. Pharmacol. 149(1):56-64. (rat, Spain)
  • Bello SO et al. (2005) Preliminary Evaluation of the Toxicity and Some Pharmacological Properties of the Aqueous Crude Extract of Solanum Melongena. Research Journal of Agriculture and Biological Sciences 1(1): 1-9, 2005. (mouse, Nigeria)
  • Ratnasooriya WD et al. (2005) Anti-inflammatory Activity of the Aqueous Leaf Extract of Ixora coccinea. Int. J. Pharmacognosy, 43(2): 147-152. (rat, Sri Lanka).
  • Gaitan G et al. (2004) Comparison of the antinociceptive activity of two new NO-releasing derivatives of the NSAID S-ketoprofen in rats. Br J Pharmacol. 143(5):533-40. (rat, Spain).
  • Park HJ et al. (2004) Antiarthritic effect of bee venom: Inhibition of inflammation mediator generation by suppression of NF-B through interaction with the p50 subunit. Arthritis & Rheumatism, 50(11): 3504-3515. (rat, South Korea)
  • Vongtau HO et al. (2004) Anti-nociceptive and anti-inflammatory activities of the methanolic extract of Parinari polyandra stem bark in rats and mice. J Ethnopharmacol. 2004 Jan;90(1):115-21. (rat, Nigeria)
  • Adzu B et al. (2003) Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis. J Ethnopharmacol. 2003 Feb;84(2-3):169-73. (rat, Nigeria)
  • Adzu B et al. (2002) Pharmacological evidence favouring the folkloric use of Diospyros mespiliformis Hochst in the relief of pain and fever. J Ethnopharmacol. 2002 Oct;82(2-3):191-5. (rat, Nigeria)
  • Amos S et al. (2002) Anti-Inflammatory and Anti-Nociceptive Effects of Ficus platyphylla Extract in Mice and Rats. Journal of Herbs, Spices & Medicinal Plants, Volume 9, Issue 1, 2002, p47-53. (mouse, rat, Nigeria)
  • Chidume FC et al. (2001) Pharmacological activity of the methanolic extract of Cassia nigricans leaves. Indian J. Pharmacol. 33: 350-356. (rat, Nigeria)
  • Kapu SD et al. (2001) Antiplasmodial, analgesic, and anti-inflammatory activities of the aqueous extract of the stem bark of Erythrina senegalensis. J Ethnopharmacol. 2000 Jul;71(1-2):275-80. (rat, Nigeria)
  • Amos S et al. (2000) Anti-Inflammatory and Anti-Nociceptive Effects of Ficus platyphylla Extract in Mice and Rats. J. Herbs, Spices Med. Plants, 9(1): 47-53. (mouse, rat, Nigeria)
  • Planas E et al. (2000) Antinociceptive/Anti-Edema Effects of Liposomal Morphine during Acute Inflammation of the Rat Paw Pharmacology 60:121-127 (rat, Spain)
  • Saidu K et al. (2000) Antiplasmodial, analgesic, and anti-inflammatory activities of the aqueous extract of the stem bark of Erythrina senegalensis. J Ethnopharmacol. 2000 Jul;71(1-2):275-80. (rat, Nigeria)
  • Turull A, Queralt J (2000) Effect of the COX-2 Selective Inhibitor L-745,337 on Inflammation and Organ Prostaglandin E2 (PGE2) Levels in Adjuvant Arthritic Rats. Inflammation, 24(6): 533-545 (rat, Spain)
  • Vongtau HO et al. (2000). Pharmacological effects of the aqueous extract of< i> Neorautanenia mitis in rodents. Journal of ethnopharmacology, 72(1), 207-214. (Nigeria)
  • Meishiang J et al. (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275(5297): 218-220. (rat, USA)
  • Pelegri C et al. (1996) Treatment with an anti-CD4 monoclonal antibody strongly ameliorates established rat adjuvant arthritis. Clin Exp Immunol. 103(2):273-8 (rat, Spain).

 

How to order

CONTROL UNIT

LE7500

76-0220

Digital Water Plethysmometer (cell with electrode and calibrator, as well as SEDACOM software option should be purchased separately)

 

CELL/ELECTRODE SYSTEM & CALIBRATOR

LE7504

76-0221

1 ml cell with electrode and 1 ml calibrator

LE7503

76-0223

3 ml cell with electrode and 3 ml calibrator

LE7505

76-0222

5 ml cell with electrode and 5 ml calibrator

  

DATA TRANSFER & SOFTWARE

SEDACOM V2.0

76-0406

SeDaCom V2.0 software for data transfer to a computer

CONRS232USB

76-0608

SeDaCom accessory - RS232/USB adapter

LE7000

76-0114

Thermal Printer

  

SPARE PARTS 

LE75301

76-0225

1 ml calibrator for Plethysmometer

LE75303

76-0226

3 ml calibrator for Plethysmometer

LE75305

76-0436

5 ml calibrator for Plethysmometer

LE7506

76-0224

Platinum electrode

How to order

Please contact our local delegates or contact us directly for receiving a quote.

 

Key features

  • Automatic zero adjustment
  • “Check solution” status button
  • Foot-switch control
  • New optional Data Transfer software SEDACOM 2.0

 

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