STATIC WEIGHT BEARING - INCAPACITANCE TEST

For assessing spontaneous pain in rodents

Description
Key features
Specs
How to order
Publications

Description

The Incapacitance test (static weight bearing test) represents an unsurpassed method for assessing spontaneous pain in laboratory animal model with inflammation or nerve injury in one hind paw (neuropathy, carrageenin, incision…). Indeed, classic measurements of nociceptive thresholds as used in most of the experimental studies allows assessment of only a pain sensitivity level, not a spontaneous pain level, in the absence of experimental nociceptive stimuli. 

In the incapacitance test, the animal is located in a holder specially designed to maintain the animal comfortably positioned on two separated sensor plates. The Panlab Incapacitance tester enables then to quantify the spontaneous postural changes reflecting spontaneous pain by independently measuring the weight that the animal applies each hind paw on two separate sensors. In the absence of hind paw injury, rats applied equal weight on both hind paws, indicating a postural equilibrium. After unilateral hind paw tissue injury, a change in the weight distribution on the sensor can be detected, with a lower weight applied by the injured paw. 

The current value of the weight applied on each sensor cell is shown on the LCD display of the LE7950 control unit in a user-selected unit (grams, Newton or oz/lbs). Now with a brand new touch-screen console! A remote foot-switch controls the test start/stop allowing rapid hands-free experiments. The control unit also allows to compute and display statistics (mean, sd) for the groups of animals under test during the measurements. No PC is required for running the incapacitance test, although the possibility is given to send collected data from the instrument to a PC through the integrated RS232 interface SEDACOM. 

The new SEDACOM 2.0 version (optional) provides an easy and convenient way to visualize and export the data on a computer for further analysis.

Specs

Accuracy 0.2% F.S.
Average 1 to 300 seconds
Overpressure 2000 gr
Control Unit Dimensions 17 x 25 x 10 cm
Communications USB

Publications

  • Mohan G et al. (2013) Pre-emptive, early, and delayed alendronate treatment in a rat model of knee osteoarthritis: effect on subchondral trabecular bone microarchitecture and cartilage degradation of the tibia, bone/cartilage turnover, and joint discomfort. Osteoarthritis and Cartilage, Volume 21, Issue 10, Pages 1595–1604. (rat, Australia)
  • Vaysse L et al. (2011) GABAergic pathway in a rat model of chronic neuropathic pain: Modulation after intrathecal transplantation of a human neuronal cell line. Neurosci. Res. 69(2):111-120. (rat, Neuropathy, France)
  • Tétreault P et al. (2011) Weight bearing evaluation in inflammatory, neuropathic and cancer chronic pain in freely moving rats. Physiology & Behavior, Volume 104, Issue 3, Pages 495–502. (rat, Canada)
  • LaboureyrasE et al. (2009) Long-Term Pain Vulnerability After Surgery in Rats: Prevention by Nefopam, an Analgesic with Antihyperalgesic Properties. Anesth. Analg. 109:623-631. (rat, France)
  • Liu S et al. (2009) Combination of Microsurgery and Gene Therapy for Spinal Dorsal Root Injury Repair. Mol. Ther. 17(6):992-1002. (rat, France)
  • Rivat C et al. (2008) Polyamine deficient diet to relieve pain hypersensitivity. Pain. 137(1):125-137 (Rat, France)
  • Richebé P et al. (2009) Ketamine Improves the Management of Exaggerated Postoperative Pain Observed in Perioperative Fentanyl-treated Rats. Anesthesiology. 102(2):421-428. (rat, France)

 

How to order

CONTROL UNIT & STIMULUS

LE7900

76-0115

Incapacitance Test Sensors pad.

LE7920

76-0116

Incapacitance Test - recipient for mouse.

LE7930

76-0117

Incapacitance Test - recipient for rat.

LE7950

76-0118

Incapacitance Test control unit.

 

BASIC DATA TRANSFER 

SEDACOM

76-0406

SeDaCom V2.0 software for data transfer to a computer.

How to order

Please contact our local delegates or contact us directly for receiving a quote.

 

Key features

  • Assess spontaneous pain in absence of the application any experimental noxious or non-noxious stimulus
  • Specially designed animal holders (Mouse and rat) to get relevant results in a more rapid manner
  • Now with a brand new touch-screen console!
  • Data given using user selected unit (grams, Newton, oz/lbs)
  • Easy and precise instrument

 

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